Saw this recently and was pleasantly surprised. I have never heard of Amy Schumer before this but I liked her as a leading lady. She definitely can carry comedy and even her emotional scenes were believable. Her movie character is bit too unlikable and Bill Hader's character was a bit too perfect for my taste, but I liked them both and they had good chemistry together.
The leads were great, but the supporting cast is what makes this movie really good. John Cena? Best part of the movie for me; absolutely hilarious and wish there was more. Lebron James was surprisingly quite good, probably better than Jordan and Kobe in terms of acting. The smaller roles and cameos were great and wow, Tilda Swinton with a tons of make up and a make over looked quite good! Took me a few minutes to recognize her and Brie Larson was very nice eye candy too.
This is a comedy geared towards woman, but has laughs and moments and characters that guys can definitely enjoy this too. Right now I'd say this was the best mainstream comedy I've seen this year. Highly recommended and watching it in a theater with other audience members will increase your enjoyment.